A clinical study conducted by mariedm Co., Ltd. Skin Research Center on [the effects of oral intake of Lactic Acid Bacterium Fermented Rice Germ Extract (LFRGE)

on human skin] was published online in the international peer-reviewed journal Food Science and Biotechnology on December 12, 2025, via the Springer Nature platform.

The study was designed as a randomized, double-blind, placebo-controlled clinical trial, involving 111 participants who consumed LFRGE for 12 weeks.

Researchers evaluated changes in multiple skin aging-related parameters following supplementation.

Compared with the placebo group, participants who consumed LFRGE showed significant improvements in wrinkle severity, skin elasticity, skin hydration, and dermal density.

In addition, transepidermal water loss (TEWL) was significantly reduced, indicating enhanced skin barrier function. No adverse events were reported during the study, confirming the safety and tolerability of LFRGE.

LFRGE contains gamma-aminobutyric acid (GABA) and has previously been reported to regulate skin aging- and barrier-related biomarkers, including matrix metalloproteinase-1 (MMP-1), filaggrin,

and aquaporin-3 (AQP3). The findings of this clinical trial further support its beneficial effects on human skin health.

Food Science and Biotechnology is an international scientific journal in the fields of food science and biotechnology, published by the Korean Society of Food Science and Technology (KoSFoST).

The journal is indexed in major scientific databases, including SCIE, and has a 2024 Journal Impact Factor of 3.1.

The published paper is titled "Effect of Oral Intake of Lactic Acid Bacterium Fermented Rice Germ Extract (LFRGE) on Human Skin: A Randomized, Double-Blinded, Placebo-Controlled Study."

The research was conducted collaboratively by mariedm Co., Ltd. Skin Research Center and NUTRI Co., Ltd., with Yuri Park as the first author and Miyeong Lee as the corresponding author.

The full article is available through the link below. : https://link.springer.com/article/10.1007/s10068-025-02075-8